THE FORKHEAD TRANSCRIPTION FACTOR FOXL2 IS SUMOYLATED IN BOTH HUMAN AND MOUSE: SUMOYLATION AFFECTS ITS STABILITY, LOCALIZATION, AND ACTIVITY.

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.

The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure.Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and ovary development and rev

read more

Expanding the National Drug Abuse Treatment Clinical Trials Network to address the management of substance use disorders in general medical settings

Betty Tai, Steven Sparenborg, Udi E Ghitza, David Liu Center for the Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA Abstract: The Patient Protection and Affordable Care Act (2010) and the Mental Skin Cream Health Parity and Addiction Equity Act (2008) expand substance use disorder (

read more

The Influence of Micro-Oxygen Addition on Desulfurization Performance and Microbial Communities during Waste-Activated Sludge Digestion in a Rusty Scrap Iron-Loaded Anaerobic Digester

In this study, micro-oxygen was integrated into a rusty scrap iron (RSI)-loaded anaerobic digester.Under an optimal RSI dosage of 20 g/L, increasing O2 levels were added stepwise in seven stages in a semi-continuous experiment.Results showed the average methane yield was 306 mL/g COD (chemical oxygen demand), and the hydrogen sulphide (H2S) concent

read more

Quantum Measurements from a Logical Point of View

We introduce a logic modelling some aspects of the behaviour of the measurement process, in such a way that no Feeding direct mention of quantum states is made, thus avoiding the problems associated to this rather evasive notion.We then study some properties of the models of this logic, and deduce some characteristics that any model (and hence, any

read more